Tuesday, March 12, 2013

Antibiotic resistance 'has the potential to undermine modern health systems'

Antibiotic resistance 'has the potential to undermine modern health systems' [ Back to EurekAlert! ] Public release date: 11-Mar-2013
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Contact: Emma Dickinson
edickinson@bmjgroup.com
44-020-738-36529
BMJ-British Medical Journal

Apocalyptic scenario may be looming if we don't act now, say experts

Their warning comes as the Chief Medical Officer launches the UK's Antimicrobial Resistance Strategy and Action Plan, reflecting the need for a clear change in our understanding of and response to antimicrobial resistance by the public, NHS and government.

Current estimates suggest that antibiotic resistance is a relatively cheap problem, they write, but such estimates do not take account of the fact that antimicrobial medicines are integral to modern healthcare. For example, antibiotics are given as standard to patients undergoing surgery, to women delivering by caesarean section, and to those having cancer treatment.

"From cradle to grave, antimicrobials have become pivotal in safeguarding the overall health of human societies," they write.

Although it is difficult to forecast the likely economic burden of resistance, they believe that even the highest current cost estimates "provide false reassurance" and this may mean that inadequate attention and resources are devoted to resolving the problem.

For example, current infection rates for patients undergoing hip replacement are 0.5-2%, so most patients recover without infection, and those who have an infection have it successfully treated. But the authors estimate that, without antibiotics, the rate of postoperative infection could be 40-50% and about 30% of those with an infection could die.

While they recognise that this is a simplistic analysis, they say "we use it as an example to illustrate and provoke, to emphasise the point that infection rates and their consequences in terms of health service costs and human health may be unimaginable."

A change in culture and action is needed to plan for a future with more antibiotic resistance, they conclude. "Waiting for the burden to become substantial before taking action may mean waiting until it is too late. Rather than see expenditure on antimicrobial policies as a cost, we should think of it as an insurance policy against a catastrophe; albeit one which we hope will never happen."

In an accompanying editorial, Professors Anthony Kessel and Mike Sharland say the new UK Five Year Antimicrobial Resistance Strategy and Action Plan "represents an important step in both recognising and responding to this significant threat."

The problems are global and the terminology complex, but the importance is clear, they write. "A fundamental standard of the NHS should include basic high quality routine infection control and clinical care, as noted by the Francis inquiry. These standards of care are crucial to the prevention and control of all healthcare associated infections, including multi-drug resistant Gram negative bacteria."

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Antibiotic resistance 'has the potential to undermine modern health systems' [ Back to EurekAlert! ] Public release date: 11-Mar-2013
[ | E-mail | Share Share ]

Contact: Emma Dickinson
edickinson@bmjgroup.com
44-020-738-36529
BMJ-British Medical Journal

Apocalyptic scenario may be looming if we don't act now, say experts

Their warning comes as the Chief Medical Officer launches the UK's Antimicrobial Resistance Strategy and Action Plan, reflecting the need for a clear change in our understanding of and response to antimicrobial resistance by the public, NHS and government.

Current estimates suggest that antibiotic resistance is a relatively cheap problem, they write, but such estimates do not take account of the fact that antimicrobial medicines are integral to modern healthcare. For example, antibiotics are given as standard to patients undergoing surgery, to women delivering by caesarean section, and to those having cancer treatment.

"From cradle to grave, antimicrobials have become pivotal in safeguarding the overall health of human societies," they write.

Although it is difficult to forecast the likely economic burden of resistance, they believe that even the highest current cost estimates "provide false reassurance" and this may mean that inadequate attention and resources are devoted to resolving the problem.

For example, current infection rates for patients undergoing hip replacement are 0.5-2%, so most patients recover without infection, and those who have an infection have it successfully treated. But the authors estimate that, without antibiotics, the rate of postoperative infection could be 40-50% and about 30% of those with an infection could die.

While they recognise that this is a simplistic analysis, they say "we use it as an example to illustrate and provoke, to emphasise the point that infection rates and their consequences in terms of health service costs and human health may be unimaginable."

A change in culture and action is needed to plan for a future with more antibiotic resistance, they conclude. "Waiting for the burden to become substantial before taking action may mean waiting until it is too late. Rather than see expenditure on antimicrobial policies as a cost, we should think of it as an insurance policy against a catastrophe; albeit one which we hope will never happen."

In an accompanying editorial, Professors Anthony Kessel and Mike Sharland say the new UK Five Year Antimicrobial Resistance Strategy and Action Plan "represents an important step in both recognising and responding to this significant threat."

The problems are global and the terminology complex, but the importance is clear, they write. "A fundamental standard of the NHS should include basic high quality routine infection control and clinical care, as noted by the Francis inquiry. These standards of care are crucial to the prevention and control of all healthcare associated infections, including multi-drug resistant Gram negative bacteria."

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/bmj-ar031113.php

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Saturday, March 9, 2013

Broadband Nearby Loops for Higher-Speed Internet Access (Artech ...

Broadband Local Loops for High-Speed Internet Access (Artech House Telecommunications Library)
A study of broadband access technologies for engineers working for telecommunications carriers and Net service providers. It provides professionals an in-depth understanding of unbundling for voice and data solutions, and gives guidance on hardware considerations and vital communication protocols. There is coverage of the numerous alternatives for the consumer premises, such as home networking, single gear buyer premises, and multi-equipment buyer premises. Supported by almost 250 illustrations and over 120 equations, the manual covers a wide range of crucial topics to assist experts with their operate in the field.

This entry was posted in Broadband and tagged Access, Artech, Broadband, HigherSpeed, Internet, Library, Loops, Nearby, Property, Telecommunications on by sweetnanas.

Source: http://www.syzysy.com/broadband-nearby-loops-for-higher-speed-internet-access-artech-property-telecommunications-library.html

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Friday, March 8, 2013

Bill Clinton says anti-gay marriage law he signed should be overturned (reuters)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/289906139?client_source=feed&format=rss

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Genetic study of house dust mites demonstrates reversible evolution

Mar. 8, 2013 ? In evolutionary biology, there is a deeply rooted supposition that you can't go home again: Once an organism has evolved specialized traits, it can't return to the lifestyle of its ancestors.

There's even a name for this pervasive idea. Dollo's law states that evolution is unidirectional and irreversible. But this "law" is not universally accepted and is the topic of heated debate among biologists.

Now a research team led by two University of Michigan biologists has used a large-scale genetic study of the lowly house dust mite to uncover an example of reversible evolution that appears to violate Dollo's law.

The study shows that tiny free-living house dust mites, which thrive in the mattresses, sofas and carpets of even the cleanest homes, evolved from parasites, which in turn evolved from free-living organisms millions of years ago.

"All our analyses conclusively demonstrated that house dust mites have abandoned a parasitic lifestyle, secondarily becoming free-living, and then speciated in several habitats, including human habitations," according to Pavel Klimov and Barry OConnor of the U-M Department of Ecology and Evolutionary Biology.

Their paper, "Is permanent parasitism reversible? -- Critical evidence from early evolution of house dust mites," is scheduled to be published online March 8 in the journal Systematic Biology.

Mites are arachnids related to spiders (both have eight legs) and are among the most diverse animals on Earth. House dust mites, members of the family Pyroglyphidae, are the most common cause of allergic symptoms in humans, affecting up to 1.2 billion people worldwide.

Despite their huge impact on human health, the evolutionary relationships between these speck-sized creatures are poorly understood. According to Klimov and OConnor, there are 62 different published hypotheses arguing about whether today's free-living dust mites originated from a free-living ancestor or from a parasite -- an organism that lives on or in a host species and damages its host.

In their study, Klimov and OConnor evaluated all 62 hypotheses. Their project used large-scale DNA sequencing, the construction of detailed evolutionary trees called phylogenies, and sophisticated statistical analyses to test the hypotheses about the ancestral ecology of house dust mites.

On the phylogenetic tree they produced, house dust mites appear within a large lineage of parasitic mites, the Psoroptidia. These mites are full-time parasites of birds and mammals that never leave the bodies of their hosts. The U-M analysis shows that the immediate parasitic ancestors of house dust mites include skin mites, such as the psoroptic mange mites of livestock and the dog and cat ear mite.

"This result was so surprising that we decided to contact our colleagues to obtain their feedback prior to sending these data for publication," said Klimov, the first author of the paper and an assistant research scientist in the Department of Ecology and Evolutionary Biology.

The result was so surprising largely because it runs counter to the entrenched idea that highly specialized parasites cannot return to the free-living lifestyle of their ancestors.

"Parasites can quickly evolve highly sophisticated mechanisms for host exploitation and can lose their ability to function away from the host body," Klimov said. "They often experience degradation or loss of many genes because their functions are no longer required in a rich environment where hosts provide both living space and nutrients. Many researchers in the field perceive such specialization as evolutionarily irreversible."

The U-M findings also have human-health implications, said OConnor, a professor in the Department of Ecology and Evolutionary Biology and a curator of insects and arachnids at the U-M Museum of Zoology.

"Our study is an example of how asking a purely academic question may result in broad practical applications," he said. "Knowing phylogenetic relationships of house dust mites may provide insights into allergenic properties of their immune-response-triggering proteins and the evolution of genes encoding allergens."

The project started in 2006 with a grant from the National Science Foundation. The first step was to obtain specimens of many free-living and parasitic mites -- no simple task given that some mite species are associated with rare mammal or bird species around the world.

The research team relied on a network of 64 biologists in 19 countries to obtain specimens. In addition, Klimov and OConnor conducted field trips to North and South America, Europe, Asia and Africa. On one occasion, it took two years to obtain samples of an important species parasitizing African birds.

A total of around 700 mite species were collected for the study. For the genetic analysis, the same five nuclear genes were sequenced in each species.

How might the ecological shift from parasite to free-living state have occurred?

There is little doubt that early free-living dust mites were nest inhabitants -- the nests of birds and mammals are the principal habitat of all modern free-living species in the family Pyroglyphidae. Klimov and OConnor propose that a combination of several characteristics of their parasitic ancestors played an important role in allowing them to abandon permanent parasitism: tolerance of low humidity, development of powerful digestive enzymes that allowed them to feed on skin and keratinous (containing the protein keratin, which is found in human hair and fingernails) materials, and low host specificity with frequent shifts to unrelated hosts.

These features, which occur in almost all parasitic mites, were likely important precursors that enabled mite populations to thrive in host nests despite low humidity and scarce, low-quality food resources, according to Klimov and OConnor. For example, powerful enzymes allowed these mites to consume hard-to-digest feather and skin flakes composed of keratin.

With the advent of human civilization, nest-inhabiting pyroglyphids could have shifted to human dwellings from the nests of birds and rodents living in or around human homes. Once the mites moved indoors, the potent digestive enzymes and other immune-response-triggering molecules they carry made them a major source of human allergies.

This work was supported by the National Science Foundation and also benefited, in part, from specimens collected by the Field Museum's Emerging Pathogens Project, funded by the Davee Foundation and the Dr. Ralph and Marian Falk Medical Research Trust. The molecular work was conducted in the Genomic Diversity Laboratory of the U-M Museum of Zoology.

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The above story is reprinted from materials provided by University of Michigan.

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Journal Reference:

  1. P. B. Klimov, B. OConnor. Is Permanent Parasitism Reversible? - Critical Evidence from Early Evolution of House Dust Mites. Systematic Biology, 2013; DOI: 10.1093/sysbio/syt008

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/xz9omi9iaLw/130308093424.htm

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Wednesday, March 6, 2013

'God particle': Confirmation is 'achingly close'

FILE - This 2011 image provide by CERN, shows a real CMS proton-proton collision in which four high energy electrons (green lines and red towers) are observed in a 2011 event. The event shows characteristics expected from the decay of a Higgs boson but is also consistent with background Standard Model physics processes. Physicists in Italy said Wednesday, March 6, 2013 they are closer to concluding that what they found last year was the elusive "God particle." But they still haven't reached that "Eureka moment" when they can announce the Higgs boson is found. The long theorized subatomic particle would explain why matter has mass and has been called a missing cornerstone of physics. (AP Photo/CERN)

FILE - This 2011 image provide by CERN, shows a real CMS proton-proton collision in which four high energy electrons (green lines and red towers) are observed in a 2011 event. The event shows characteristics expected from the decay of a Higgs boson but is also consistent with background Standard Model physics processes. Physicists in Italy said Wednesday, March 6, 2013 they are closer to concluding that what they found last year was the elusive "God particle." But they still haven't reached that "Eureka moment" when they can announce the Higgs boson is found. The long theorized subatomic particle would explain why matter has mass and has been called a missing cornerstone of physics. (AP Photo/CERN)

(AP) ? Physicists in Italy said Wednesday they are achingly close to concluding that what they found last year was the Higgs boson, the elusive "God particle." They need to eliminate one last remote possibility that it's something else.

The long theorized subatomic particle would explain why matter has mass and has been called a missing cornerstone of physics.

With new analyses, scientists are closer to being certain they found the crucial Higgs boson. But they want to be 99.9 percent positive, said Pauline Gagnon, a physicist with the European Center for Nuclear Research.

Last July scientists with the world's largest atom smasher, the $10 billion Large Hadron Collider on the Swiss-French border, announced finding a particle they described as Higgs-like, but wouldn't say it was conclusively the particle. Now thousands of checks show them even closer.

"It looks more and more like a Higgs boson," said Gagnon after an update presented Wednesday at a conference in the Italian Alps.

Gagnon compared finding the Higgs to identifying a specific person. This looks, talks, and sings like a Higgs, but scientists want to make sure it dances like the Higgs before they shout "Eureka."

She said there is only one last thing the particle they found could also be: a graviton. That's another subatomic particle associated with gravitational fields, not mass.

By checking the spin of the particle, scientists will be able to tell if it is a Higgs boson, which is far more likely, or a graviton. If it has no internal spin, it's the Higgs boson; if it has a lot of spin it's a graviton.

Wednesday's presentation was by one team of researchers and another team will present more findings next week.

Physicist Sean Carroll of the California Institute of Technology, who isn't involved in the research, said scientists are just being careful, covering all bases.

Without the Higgs boson to explain why electrons and matter have mass, Carroll said, "there would be no atoms, there would be no chemistry, there would be no life, so that's kind of important."

___

Online:

http://public.web.cern.ch/public/

___

Seth Borenstein can be followed at http://twitter.com/borenbears

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/b2f0ca3a594644ee9e50a8ec4ce2d6de/Article_2013-03-06-God%20Particle/id-bd4850460fa944009bb94f6fefd3741c

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Windows Server 2008 Enterprise Hijack.ControlPanelStyle

I have a unique problem.?? Vipre Antivirus missed some malware which "phones home" every minute and 40 seconds, and spike the CPU to 100% for 6-8 seconds on my Windows Server 2008 Entrerprise server.?? This server is virtualized in a VMWare environment, and runs all of our school district DHCP services.?? This is a big deal because if a device is looking for an IP during this 6-8 second period of high CPU utilization, it will just timeout, and assign a local APIPA IP causing our users to have no idea what the problem is...

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I finally found the problem by installing Malwarebytes, and it is able to remove the malware, here are the pertinent lines from the log entry:

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Windows Server 2008 Service Pack 2 x86 NTFS
Internet Explorer 9.0.8112.16421

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Registry Values Detected: 1
HKCU\SOFTWARE\Microsoft\Windows\CurrentVersion\Policies\Explorer|ForceClassicControlPanel (Hijack.ControlPanelStyle) -> Data: 1 -> Quarantined and deleted successfully.

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However, the moment that I restart the server, it comes right back.

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If this was a Windows 7 PC, the forums talk about using the Combofix.exe utility, but it doesn't run on a server.

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I have looked in the Registry Run Once and Run keys, and found nothing...?? Does anyone know where this bugger might be hiding?

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Any help would be much appreciated!


Source: http://www.bleepingcomputer.com/forums/topic487606.html

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